Calcium, mitochondria, and Alzheimer’s

Published May 12, 2020

It’s com­mon knowl­edge (well, sort of) that Alzheimer’s patients have a buildup of amy­loid beta plaques in their brain tis­sue, but every treat­ment tar­get­ing the plaque has failed.

Neurologists at Mass General have some new infor­ma­tion — and a poten­tial new tar­get for treat­ment: high lev­els of cal­ci­um in the mito­chon­dria of mice with Alzheimer’s.

What this means: Instead of tar­get­ing the amy­loid beta plaques, it might be bet­ter to tar­get the “neu­ronal mito­chon­dr­i­al cal­ci­um uni­porter” — the mech­a­nism that over­loads the mitochondria.

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